Sure! Personally, I'd reshape it for good polar response integration to whatever HF horn pattern through the XO BW and to get away from any parallel walls.
The 210 is tuned to ~35 Hz with dual vents, so halve the cab and number of drivers, vents and it's still ~35 Hz. For best SQ/max dynamics though, using a sealed rear chamber XO'd to a ~matching (highly damped, efficient) 'sub' system is the way to go.
GM

